Clinical Features, Diagnosis and the Social brain in autism. Karen Pierce, UCSD Neurosciences

1) Zwaigenbaum, L. Bryson, S. et al. Behavioral manifestations of autism in the first year of life. Int J. Devl Neuroscience 2005; 23: 143-152

2) Pierce, K., Haist, F., Sedaghat, F., and Courchesne, E. The brain response to personally familiar faces in autism: findings of fusiform activity and beyond. Brain. 2004 Dec;127(Pt 12):2703-16

10/10

Neuroanatomy of Autism: Postmortem, in vivo. Eric Courchesne, UCSD Neurosciences

1) Courchesne et al. (2001) Unusual brain growth patterns in earlylife in patients with autistic disorder: An MRI study

2) Schumann & Amaral (2006) Stereological Analysis of Amygdala Neuron Number in Autism

10/17

Genetics. Tony Wynshaw- Boris, UCSD Pediatrics

Readings
1) Autism Genome Consortium,  Mapping autism risk loci using genetic linkage and chromosomal rearrangements . Nat Genet, 2007. 39(3): p. 319-28.
2) Nishimura, Y., C.L. Martin, A. Vazquez-Lopez, S.J. et al., Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways . Hum Mol Genet , 2007. 16(14): p. 1682-98.
3) Sebat, J., B. Lakshmi, D. Malhotra, J. et al., Strong association of de novo copy number mutations with autism . Science , 2007. 316(5823): p. 445-9.

10/24

CAMPUS CLOSED

Lecture moved to 11/28

10/31

Multivariate Models of Complex Disorders. Nicholas Schork, UCSD Psychiatry & Family & Preventive Medicine

Readings

1) Schellenberg, G.D., et al., Evidence for multiple loci from a genome scan of autism kindreds. Mol Psychiatry, 2006. 11 (11): p. 1049-60, 979.

2) Chen, G.K., N. Kono, D.H. Geschwind and R.M. Cantor, Quantitative trait locus analysis of nonverbal communication in autism spectrum disorder. Mol Psychiatry, 2006. 11(2): p. 214-20.

3) Duvall, J.A., A. Lu, R.M. Cantor, R.D. Todd, J.N. Constantino and D.H. Geschwind, A quantitative trait locus analysis of social responsiveness in multiplex autism families. Am J Psychiatry, 2007. 164(4): p. 656-62.

4) Schork, N.J., T.A. Greenwood and D.L. Braff, Statistical genetics concepts and approaches in schizophrenia and related neuropsychiatric research . Schizophr Bull , 2007. 33(1): p. 95-104.

Readings from 10/17 to be discussed from prospective of this topic.

1) Nishimura, Y., C.L. Martin, A. Vazquez-Lopez, S.J. et al., Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways . Hum Mol Genet , 2007. 16(14): p. 1682-98.

2) Sebat, J., B. Lakshmi, D. Malhotra, J. et al., Strong association of de novo copy number mutations with autism . Science , 2007. 316(5823): p. 445-9.

11/7

Mirror Neuron System in Autism. Dan Kennedy, Caltech

Readings

1)  Dapretto, M., M.S. Davies, J.H. Pfeifer, A.A. Scott, M. Sigman, S.Y. Bookheimer and M. Iacoboni, Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders . Nat Neurosci , 2006. 9(1): p. 28-30.

2)  Kennedy, D.P., E. Redcay and E. Courchesne, Failing to deactivate: resting functional abnormalities in autism . Proc Natl Acad Sci U S A, 2006. 103(21): p. 8275-80.

3) Catmur, C., V. Walsh and C. Heyes, Sensorimotor learning configures the human mirror system . Curr Biol , 2007. 17(17): p. 1527-31.

Slides from lecture.

11/14

Neurodevelopmental Bases of Language Impairment in ASD. Axel Mueller, SDSU Psychology

Readings

1) Just, M. A., V. L. Cherkassky, T. A. Keller and N. J. Minshew (2004). "Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity." Brain 127 : 1811-1821.

2) Müller, R. A. (2007). "The study of autism as a distributed disorder." Ment Retard Dev Disabil Res Rev 13 (1): 85-95.

Sensory Processing in Autism. Rita Ceponiene, UCSD Center for Research in Language

Readings

1) Lepisto, T., T. Kujala, R. Vanhala, P. Alku, M. Huotilainen and R. Naatanen (2005). The discrimination of and orienting to speech and non-speech sounds in children with autism. Brain Res 1066 (1-2): 147-57.

2) Rubenstein, J. L. and M. M. Merzenich (2003). Model of autism: increased ratio of excitation/inhibition in key neural systems. Genes Brain Behav 2 : 255-67.

3) Kellerman, G. R., J. Fan and J. M. Gorman (2005). "Auditory abnormalities in autism: toward functional distinctions among findings." CNS Spectr 10 (9): 748-56. Read online or print http://www.cnsspectrums.com/aspx/articledetail.aspx?articleid=190

11/28

Attention and Perceptual Processing in Autism. Jeanne Townsend, UCSD Neurosciences

Readings

1) Allen, G. & Courchesne, E. ATTENTION FUNCTION AND DYSFUNCTION IN AUTISM. Frontiers in Bioscience, 2001. 6:105-115.

2) Buschman, T. & Miller, E. Top-Down Versus Bottom-Up Control of Attention in the Prefrontal and Posterior Parietal Cortices. Science, 2007. 315 (1860).

3) Mottron et al. Enhanced Perceptual Functioning in Autism: An Update, and Eight Principles of Autistic Perception. J. of Autism and Developmental Disorders, 2006.